— SERVICE DETAIL

Regenerative Aesthetics.

At Art of Aesthetics in Frederick, Maryland, regenerative treatments are designed to support your body's natural ability to restore, repair, and renew. Improving skin quality, collagen production, under-eye rejuvenation, and overall tissue health through advanced biologically supportive options.

On this page

— TREATMENTS

Where aesthetics is moving in 2026.

Away from obvious overfilling and toward subtle, natural, collagen-supportive, long-term rejuvenation. These treatments reflect a growing understanding that the most beautiful results come from working with the body, not against it.

PRFM Bio-Filler Under-Eye Renewal

$600

PRFM Under-Eye Autologous Hollowness Crepey Texture

PRFM, or platelet-rich fibrin matrix, is made from a small sample of your own blood. That sample is processed to concentrate platelets, fibrin, and growth factors, which are then converted into a soft gel-like consistency — allowing it to provide delicate volume support using your own biologic material rather than a traditional synthetic filler.

PRFM Bio-Filler Under-Eye Renewal is designed for clients who look tired even when they feel rested. It may help improve the appearance of under-eye hollowness, crepey texture, fine lines, mild darkness related to thin skin, and overall under-eye skin quality. Most clients benefit from a series of 2 to 3 treatments spaced 4 to 6 weeks apart.

Best for Tired-looking eyes, mild hollowing, crepey texture, fine lines, thin under-eye skin, and clients wanting a natural regenerative option. Less ideal for severe under-eye bags, significant laxity, or clients seeking dramatic instant volume.

PRFM Bio-Filler Facial Volume Restoration

From $600

PRFM Selphyller Gel Facial Volume Autologous Soft Support

PRFM Bio-Filler Facial Volume Restoration provides soft, natural-looking support in areas where the face looks depleted, hollow, or tired. Because it is made from your own blood components, it is a good option for clients who want subtle facial rejuvenation without relying entirely on traditional dermal fillers.

This treatment may help improve facial softness, skin texture, early volume loss, and overall tissue quality. It is best for clients who want regenerative refinement rather than sharp contouring or dramatic reshaping. Some clients begin with one treatment and reassess at 8 to 12 weeks, while others benefit from a series.

Best for Soft facial volume support, mild hollowing, early facial depletion, skin-quality improvement, and clients who prefer an autologous treatment. Less ideal for clients needing major structural lifting or highly predictable filler-style projection.

Hyperdilute Radiesse Skin Firming

From $900

Radiesse Collagen Elastin Skin Firming Neck · Décolleté

Hyperdilute Radiesse is used more like a skin-firming biostimulator than a traditional filler. When diluted, Radiesse can be placed more superficially to support collagen and elastin production, helping improve the look of skin firmness, texture, crepiness, and laxity without adding significant volume.

This treatment may be used on the lower face, neck, décolletage, hands, arms, and other appropriate areas depending on candidacy. Best reassessment window is 3 to 6 months as collagen and elastin support develops gradually.

Best for Skin laxity, crepey texture, neck and lower-face firming, hands, décolleté, and clients wanting skin-quality improvement without obvious volume. Less ideal for clients needing immediate volume replacement or with active infection in the treatment area.

Common Questions

Frequently asked questions.

Regenerative Aesthetics — General

Traditional injectables like neuromodulators and hyaluronic acid fillers work by relaxing muscles or adding volume directly. Regenerative treatments take a different approach — they work with your body's own biology to support collagen production, improve tissue quality, and restore the conditions that allow your skin to look and age better over time. The results are more gradual but tend to look very natural because the improvement comes from within.

Yes — when performed by an experienced, trained injector. PRFM uses your own blood components, which eliminates the risk of allergic reaction to a foreign substance. Sculptra and Hyperdilute Radiesse are FDA-approved treatments with established safety profiles. As with all injectable treatments, side effects such as temporary swelling, redness, or bruising at the injection site are possible. All candidacy factors, risks, and aftercare will be discussed thoroughly at your consultation.

Yes, and this is often where the best results come from. Regenerative treatments work particularly well alongside neuromodulators, dermal fillers, and advanced skin therapies as part of a longer-term aesthetic plan. For example, Sculptra may be used to build collagen support over time while neuromodulators address dynamic lines in the shorter term. Your personalized plan will account for the right combination and sequencing based on your goals.

PRFM Bio-Filler

Both PRFM and PRP use a small sample of your own blood, which is processed to concentrate platelets and growth factors. The key difference is in how the platelets are prepared. PRP, or platelet-rich plasma, produces a liquid that is injected directly. PRFM, or platelet-rich fibrin matrix, takes the process one step further — the platelets are suspended in a fibrin scaffold, which holds growth factors in place longer and allows for a more controlled, sustained release. PRFM can also be converted into a soft gel called Selphyller, which allows it to be used for subtle volume support in delicate areas like the under-eyes.

A small blood draw is required before the PRFM treatment — similar to a routine blood test. The sample is then processed in a centrifuge to concentrate the platelets and fibrin before being used for treatment. Topical numbing is applied to the treatment area for comfort. Most clients find the process very tolerable. You should arrive well hydrated on the day of your appointment, as this makes the blood draw easier.

Most clients benefit from a series of 2 to 3 treatments spaced about 4 to 6 weeks apart, depending on the degree of concern, skin quality, and individual response. Some clients notice subtle softening or brightness after the first session once initial swelling settles. More meaningful changes in texture, crepiness, and skin quality are typically evaluated around 8 to 12 weeks after beginning treatment.

For the right candidate, yes. PRFM Bio-Filler Under-Eye Renewal is particularly well-suited for clients who have experienced puffiness or a bluish tint with traditional hyaluronic acid fillers, or who have very thin, crepey under-eye skin that needs regenerative support rather than volume. It is also a good option for clients who prefer an autologous treatment — one made entirely from their own biology. It is not the right choice for everyone, particularly those with significant hollowing or fat pad loss, and candidacy will be discussed thoroughly at your consultation.

Sculptra

Dermal fillers add immediate, physical volume to specific areas and can be dissolved if needed. Sculptra works differently — it does not add volume directly, but instead stimulates your own collagen production gradually over weeks to months. The results look different too: rather than a noticeable change in a specific area, Sculptra tends to produce an overall improvement in facial fullness, structure, and skin quality that looks very natural. Results typically last longer than traditional fillers, with FDA clinical data indicating up to 24 months.

Sculptra results are gradual by design. Some clients notice early changes around 4 to 6 weeks as initial collagen production begins, with more visible improvement developing over the following months. The full effect of a treatment series is typically appreciated at around 3 to 6 months. This gradual timeline is part of what makes Sculptra results look so natural — the change happens slowly, the way healthy aging does.

The 5-5-5 rule is a standard Sculptra aftercare protocol: massage the treated area for 5 minutes, 5 times a day, for 5 days after treatment. This helps ensure even distribution of the product and reduces the risk of nodule formation. Detailed aftercare instructions including this protocol will be provided at your appointment.

Hyperdilute Radiesse

Standard Radiesse is used as a traditional dermal filler — injected to add volume and structure to specific areas. Hyperdilute Radiesse is the same product, but significantly diluted before injection. This allows it to be placed in a thinner layer, more superficially, across a broader area. At this dilution, the focus shifts from adding volume to stimulating collagen and elastin production — making it a skin-quality and firming treatment rather than a contouring one. It is particularly effective for areas like the neck, décolletage, and hands where traditional filler placement is not appropriate.

Most clients receive 1 to 3 sessions depending on the treatment area, degree of laxity, and desired result. Results develop gradually as collagen and elastin support builds — the best reassessment window is 3 to 6 months after your last session. Maintenance treatments may be recommended based on your response and long-term goals.

General

General preparation is similar to other injectable treatments — avoid blood-thinning medications and supplements such as ibuprofen, aspirin, fish oil, vitamin E, and alcohol for 24 to 48 hours before your appointment if medically appropriate. For PRFM treatments specifically, arriving well hydrated is especially important as it makes the blood draw easier and more comfortable. Specific preparation guidance will always be provided based on your health history and the treatment planned.

A complimentary consultation is the best place to start. Regenerative treatments are an evolving area of aesthetics, and many clients come in curious but unfamiliar — that is completely normal. The consultation is a no-pressure opportunity to ask questions, understand your options, and learn what might actually be appropriate for your anatomy and goals. There is no obligation to book treatment at that visit.

Regenerative Aesthetics.

Where aesthetics is moving in 2026.

PRFM Bio-Filler Under-Eye Renewal

PRFM Bio-Filler Facial Volume Restoration

Hyperdilute Radiesse Skin Firming

Restoring tissue quality, not just correcting it.

What to expect,
and when.

Series of 2–3 treatments

Series of 2–3 sessions

1–3 sessions

Who is a good candidate?

Treatment Investment.

Frequently asked questions.

Curious about regenerative care?

Regenerative Aesthetics.

Where aesthetics is moving in 2026.

PRFM Bio-Filler Under-Eye Renewal

PRFM Bio-Filler Facial Volume Restoration

Hyperdilute Radiesse Skin Firming

Restoring tissue quality, not just correcting it.

What to expect,and when.

Series of 2–3 treatments

Series of 2–3 sessions

1–3 sessions

Who is a good candidate?

Treatment Investment.

Frequently asked questions.

Curious about regenerative care?

What to expect,
and when.